The Preventive Effects and Mode of Actions of Ulva Fasciata Synthesized Silver Nanoparticles in Doxorubicin-Induced Hepatotoxicity in Wistar Rats

Background: Hepatotoxicity was one of the major side effects associated with doxorubicin treatment in cancer chemotherapy. The synthesized silver nanoparticles (AgNPs) from natural products such as algae especially green is favorable means to minimize deleterious Thus, this study aimed evaluate preventive role AgNPs by Ulva fasciata (U. fasciata) against doxorubicin-induced hepatotoxicity and oxidative stress liver male Wistar rats. 
 Materials Methods: In present study, macroalga U. ethanolic extract used reducing agents reduce Ag ions Ag0. Doxorubicin-injected rats were concomitantly treated (AgNPs/U. 3 times/week oral gavage for 6 weeks.
 Results: results showed that injected a significant increase ALT, ALP GGT activities total bilirubin level well reduction serum albumin level. concurrent treatments doxorubicin-injected AgNPs/U. significantly abrogate these alterations. altered levels tumor biomarkers CA19.9 AFP pro-inflammatory cytokine, TNF-α, anti-inflammatory IL-4, animals ameliorated fasciata. Moreover, elevated mRNA expression p53 decreased treatment. association, histological changes represented severe hydropic degenerative changes, steatosis, inflammatory cell infiltration, Kupffer proliferation apoptosis remarkably improved which more potent.
 Conclusion: Based on it can be concluded counteracts toxicity suppression inflammation, apoptosis. most potent improving hepatocyte integrity architecture. Graphical Abstract